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ea0047oc6 | Spotlight on Neuroendocrine tumours | Theranostics2016

DNA damage assay in blood lymphocytes in peptide receptor radionuclide therapy patients with personalised high activities

Eberlein Uta , Scherthan Harry , Werner Rudolph A , Lapa Constantin , Bluemel Christina , Peper Michel , Buck Andreas K , Port Matthias , Lassmann Michael

Objectives: Radiation induces DNA double strand breaks (DSBs) that can be visualized and enumerated as microscopic γ-H2AX and 53BP1 foci. This study analysed the dose- and time-dependency of the DNA damage in blood lymphocytes in patients after a personalised high-activity 177Lu-DOTATATE treatment.Methods: We investigated multiple blood samples of three patients up to 96 h after personalised high-activity peptide receptor radionuclid...

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ea0047oc14 | Spotlight on Neuroendocrine tumours | Theranostics2016

⁶⁸Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors – a head-to-head comparison with DOTATOC and FDG PET/CT

Lassmann Michael , Werner Rudolf A. , Weich Alexander , Wester Hans-Juergen , Scheurlen Michael , Higuchi Takahiro , Samnick Samuel , Bluemel Christina , Rudelius Martina , Buck Andreas K. , Lapa Constantin , Herrmann Ken

Introduction: Diagnostic imaging of neuroendocrine tumors (NETs) is the domain of somatostatin receptor (SSTR) agonists as well as FDG PET/CT in dedifferentiated tumors. SSTR also serves as target for receptor directed peptide therapy. More recently, specific ligands targeting the chemokine receptor 4 (CXCR4) were introduced potentially offering an additional theranostic option in NETs. Here we evaluated the CXCR4 expression using 68Ga-Pentixafor PET/CT in NET patie...

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Endocrine Abstracts

DNA damage assay in blood lymphocytes in peptide receptor radionuclide therapy patients with personalised high activities

⁶⁸Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors – a head-to-head comparison with DOTATOC and FDG PET/CT

BiosciAbstracts

Endocrine Abstracts

DNA damage assay in blood lymphocytes in peptide receptor radionuclide therapy patients with personalised high activities

68Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors – a head-to-head comparison with DOTATOC and FDG PET/CT

BiosciAbstracts

⁶⁸Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors – a head-to-head comparison with DOTATOC and FDG PET/CT